Scientists at City of Hope have uncovered a gene called SMOC1 that plays a surprising role in the development of type 2 diabetes (T2D) by converting pancreatic cells that normally produce insulin into ...

Dysfunctions of the tiny cell processes (primary cilia) of the pancreatic beta cells could be a cause of type 2 diabetes. Little is known about the structure and function of these cilia. An ...

LOS ANGELES — Scientists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S., and a leading research center for diabetes and other ...

A hallmark of type 2 diabetes is the progressive loss of beta cell mass: cells in the pancreas that produce and release insulin. The endoplasmic reticulum stress response, a cellular pathway that ...

Type 1 diabetes is widely understood as an autoimmune disease, with the immune system attacking the insulin-producing beta ...

Our glycaemic balance is based on the ability of the pancreatic beta cells to detect glucose and secrete insulin to maintain our blood sugar levels. If these cells malfunction, the balance is broken, ...

BUENOS AIRES, Dec. 4 (UPI) --Argentine scientists have identified a mechanism that allows pancreatic beta cells, which produce insulin, to become resistant to damage. The finding opens the door to new ...

As people age, most maintain normal blood sugar even as insulin resistance tends to rise. New research suggests that pancreatic beta cells help meet this demand through gradual epigenetic changes in ...

Pancreatic beta cells are cells that produce insulin, the hormone responsible for regulating blood glucose levels. Diabetes develops when beta cells can no longer produce or secrete enough insulin to ...

GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve ...

Research on preventing type 1 diabetes often focuses on limiting the autoimmune response that destroys the body’s ability to produce its own insulin. A new technology developed by scientists at the ...