Covalent drugs block protein function by forming a specific bond between the ligand and target protein. A covalent mechanism of action can provide many pharmacological advantages over a reversible ...

A structure of the drug ibrutinib. The drug ibrutinib makes a covalent bond to Bruton's tyrosine kinase, an important cancer target. Credit: RCSB PDB/Yang H. Ku Enticing atoms to share their electrons ...

Covalent bonding close covalent bondA bond between atoms formed when atoms share electrons to achieve a full outer shell of electrons. leads to the formation of substances with different types of ...

Chemical bonding is the force of attraction that holds atoms together to form molecules or compounds. There are two primary types of chemical bonds: ionic and covalent bonds. Both these bonds play a ...