Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...
Faithful replication of the genome is essential for development, tissue homeostasis and prevention of malignancy. Key steps in eukaryotic DNA replication include the licensing of replication origins, ...
The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...
Every day, billions of cells in your body divide, helping to replace old and injured cells with new ones. And each time this happens, your entire genetic library—your genome, which totals more than 3 ...
As recently as the mid-20th century, aging was described by Nobel Prize laureate Peter Medawar as "an unsolved problem in biology." Today, scientists can analyze the activity of thousands of genes in ...
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DNA from cliffside hanging coffins tied the 3,000-year-old ritual to a people who nearly vanished
Genome-wide data extracted from human remains placed inside cliffside coffins across southern China now directly connect the ...
The DNA in a single cup of water can track wildlife, monitor pollution and survey pathogens in waterways and their ...
As genome editing therapies move through clinical trials to regulatory approval, scientists continue the quest for the holy ...
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...
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