Post-translational modification by ubiquitin and ubiquitin-like proteins (ubls) regulates almost all aspects of cellular function. Although it is known that E1, E2 and E3 enzymes work together in a ...
Ubiquitin-like proteins, including NEDD8, regulate a wide range of cellular processes and are mobilized by parallel biochemical pathways. A recent crystal structure explains how the NEDD8-specific E1 ...
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