The mevalonate pathway is central to the biosynthesis of isoprenoids and sterols, underpinning a range of essential cellular processes. Farnesyl diphosphate synthase (FPPS) is a pivotal enzyme in this ...

The mevalonate (MVA) pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, we provided evidence that p53 induces the expression of a group of ...

Among 312,907 identified patients with cancer, treatment groups included statin users (n = 65,440), nonstatin users who received medications that block cholesterol absorption (n = 9,289), and nonusers ...

The mevalonate pathway Surprisingly, analysis of the cardiac proteome revealed that proteins in the mevalonate pathway, an essential metabolic pathway, are highly expressed midway through heart ...

Schematic diagram of mouse embryonic development on the indicated days. Bottom: The mevalonate pathway produces farnesyl diphosphate for cholesterol synthesis, protein geranylgeranylation and protein ...

The paper N. Dellas et al., “Discovery of a metabolic alternative to the classical mevalonate pathway,” eLife, doi:10.7554/eLife.00672.002, 2013. The first steps ...

Physician perspectives on extrapolating data from trials testing less-intense treatment to underrepresented populations. Socioeconomic disparities in supportive therapy use and tolerance of aromatase ...

What Is Mevalonate Kinase Deficiency? Mevalonate kinase deficiency (MKD) is a disease that runs in families. A problem with your immune system causes attacks of fever and symptoms like swollen glands, ...