Fentanyl is one of the most effective drugs for managing severe pain, yet it carries substantial risks of addiction and respiratory depression, the dangerous and sometimes fatal slowed breathing.

Scripps Research scientists have re-engineered fentanyl’s core structure to retain potent analgesia while limiting respiratory depression in preclinical tests – a strategy that could inform ...

Oxycontin (oxycodone hydrochloride) prescription medications are effective at relieving pain but carry a risk of addiction. While there's a need for novel non-opioid drugs for pain, they face clinical ...

Brain volume and function are altered in individuals with opioid use disorder, a new Yale study finds. Using magnetic resonance imaging (MRI) and functional MRI (fMRI), researchers observed the ...

The combination of prescribed central nervous system stimulants, such as drugs that relieve ADHD symptoms, with prescribed opioid medications is associated with a pattern of escalating opioid intake, ...