A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure ...
Abstract: Constrained optimization is popularly seen in reinforcement learning (RL) for addressing complex control tasks. From the perspective of dynamic system, iteratively solving a constrained ...
Abstract: This paper proposes an alternating refined constraint method (ARCM) for solving multi-objective optimization problems (MOPs) in energy systems. Through a two-stage solution mechanism, ARCM ...
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