PNAS

High-affinity detection of biotinylated endogenous neuroligin-1 at excitatory and inhibitory synapses using a tagged knock-in mouse

The formation of synapses, the communication nodes between neurons, is of utmost importance in brain development. Adhesion molecules including neuroligins (NLGNs) play important roles in this process ...
Wareable

Apple Watch Series 10 vs. Series 9: Our advice after testing both

The latest Apple Watch Series 10 is the culmination of a decade of steady evolution. Yet, the company’s latest smartwatch isn’t too different from the Apple Watch Series 9 launched in 2023. When ...
C&EN

Affinity Purification Mass Spectrometry on the Orbitrap–Astral Mass Spectrometer Enables High-Throughput Protein–Protein Interaction Mapping

Department of Chemistry, University of Wisconsin–Madison, Madison, Wisconsin 53706, United States Department of Biomolecular Chemistry, University of Wisconsin–Madison, Madison, Wisconsin 53706, ...
C&EN

Current State of Open Source Force Fields in Protein–Ligand Binding Affinity Predictions

Department of Chemistry, University of California, Irvine, California 92697, United States Department of Pharmaceutical Sciences, University of California, Irvine, California 92697, United States ...
PNAS

A distinct, high-affinity, alkaline phosphatase facilitates occupation of P-depleted environments by marine picocyanobacteria

Marine picocyanobacteria are globally important primary producers, a facet facilitated via their ability to proliferate in nutrient impoverished regions of the sunlit ocean including oligotrophic ...