Abstract: The Nelder-Mead simplex method is a well-known algorithm enabling the minimization of functions that are not available in closed-form and that need not be differentiable or convex.

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How the proteins in our bodies bind together to form protein complexes plays a critical role in numerous cell functions—staving off diseases, for instance, or transporting ions across cell membranes.

It's a simple word that has developed a sinister connotation: algorithm. For many of us, algorithms help determine what we watch, read and listen to — in the process, confirming our tastes and biases, ...