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onclive.com
Treatment Approaches for TP53-Mutated AML | OncLive
Key opinion leaders in hematology oncology share insights into the challenges associated with treating patients with TP53-mutated AML and highlight the recent FDA breakthrough designation of eprenetapopt.
Sep 9, 2021
P53 Mutation
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p53 is the guardian of the genome. p53 knockout mice (-/-) are highly susceptible to formation of tumors. why? failure to detect or accurately repair DNA damage can lead to oncogenesis, particularly if the mutations are in genes controlling the cell cycle, metabolism, and/or apoptosis #biochem #molecularbiology #oncogenesis #p53 #biotok #premed
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